When it comes to bedbug bites, everyone reacts differently. Some people just have small red marks, while others have a more severe allergic reaction to the bedbug bites. The best treatment options for bedbug bites include anti-itch cream, topical antiseptics (to ward off infection), and oral antihistamines. These treatments for bedbug bites are over-the-counter. If you have a severe reaction to bedbug bites, see a doctor; you may need a corticosteroid. See Also: Is This a Bed Bite?; Are Bedbug Bites Dangerous?; and Pictures of BedBug Bites
For mild bedbug bites, an antibiotic cream is recommended. I like Neosporin + Plus Pain Relief. This maximum strength first aid antibiotic cream is available over the counter in a variety of sizes, and can be taken along while traveling.
I like the Neosporin spray for small children that don't want to have a cream rubbed on them, or are sensitive to you touching their "boo-boos." It's also extremely convenient to carry, as you can throw it in a purse or a pocket, even add it to a keyring.